A Novel Scoring System Based on Preoperative Routine Blood Test in Predicting Prognosis of Atypical Meningioma
2020
Purpose The aim of this study was to explore the correlation and clinical significance of preoperative fibrinogen and neutrophil-lymphocyte ratio F-NLR scoring system with 3-year progression-free survival PFS of patients with atypical meningioma. Material and method: Clinical, pathological, radiological, and laboratory variables were collected to analyze their correlation with 3-year PFS in the training set with 163 patients. Patients were classified by different F-NLR scores 0, 1, or 2. External validation for the predictive value of F-NLR scoring system was performed in the validation set with 105 patients. Results: Overall, 37.3% (100 of 268) of the enrolled patients were male. The scoring system showed good performance in predicting 3-year PFS AUC=0.872, 95CI=0.811-0.919, sensitivity=66.1, specificity=93.3, and Youden index=0.594. DeLong’s test indicated that the AUC of F-NLR scoring system was significantly greater than that of fibrinogen level and NLR (Z=2.929, P=0.003; Z=3.376, P0.001). Multivariate Cox analysis revealed that tumor size (HR=1.39, 95CI=1.10-1.76, P=0.007), tumor location (HR=3.11, 95CI=1.60-6.95, P=0.001), and F-NLR score (score of 1: HR=12.78, 95CI=3.78-43.08, P 0.001; score of 2: HR=44.58, 95CI=13.02-152.65, P 0.001) remained significantly associated with 3-year PFS. The good predictive performance of F-NLR scoring system was also demonstrated in the validation set (AUC=0.824, 95CI=0.738-0.891, sensitivity = 62.5, specificity = 87.9, and Youden index = 0.504). Conclusion: Our study confirmed the correlation and clinical significance of preoperative F-NLR scoring system with 3-year PFS of patients with atypical meningioma. A prospective and large-scale study is required to validate our findings.
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