Neutrophil/lymphocyte ratio (NLR) and FDG PET as predictive measures of response and prognosis in patients treated with Y-90 microsphere selective internal radionuclide therapy (SIRT).

e22137 Background: Y-90 SIRT has been increasingly utilized for treatment of liver predominant malignancies, whether primary or metastatic. Relatively little data exist regarding the prognostic value of early functional imaging response and baseline factors such as NLR. We explored the correlation between early metabolic response (EMR) on FDG PET and baseline NLR with overall survival (OS) in patients treated with SIRT. Methods: We performed a retrospective single-centre study of patients with liver-directed SIRT from 2011 to 2014. Baseline demographics, EMR on first follow-up FDG PET and NLR were correlated with OS using a Cox proportional hazards model. EMR was defined as partial or complete response of lesions in the treated liver (whether bilobar or unilobar) according to PERCIST criteria. Results: 38 patients undergoing 41 treatments were included (20 colorectal, 10 upper gastrointestinal, 5 HCC, 3 others). 17 are still alive; median age: 67 years; median follow-up: 22 months (mo). Median OS was 12.7...