Eosinophilic Esophagitis (EoE)

Eosinophilic esophagitis (EoE) was originally described in the pediatric population but in the last decade has been increasingly recognized in adults. It is a chronic inflammatory process defined by esophageal symptoms, a dense eosinophilic epithelial infiltration (>15 eosinophils/HPF), and the absence of other etiologies causing esophageal eosinophilia. The prevalence of EoE in the United States is estimated to be approximately 57 per 100,000 persons. EoE is an immune-mediated disease by which environmental and food antigens stimulate the Th2 inflammatory cascade.