Ontogenic modifications in the effect of the GABAergic system on the hypothalamic excitatory amino acids: its relationship with GABAergic control of gonadotrophin secretion during sexual maturation in female rats

Abstract Aminooxyacetic acid (AOAA), an inhibitor of γ-aminobutyric transaminase, stimulates the in vitro GABA release by medial and anterior preoptic hypothalamic areas in prepubertal female rats (6, 15 and 30 days of age). This increase of GABA release at 15 days of age, was accompanied by a significant increase ( P N -methyl- d -aspartate neurotransmission and a decrease in the release of these excitatory amino acids at 6 and 30 days of age ( P