Anti-Diabetic Activity of Leaf Extract of Nepenthes khasiana Hook on Dexamethasone Induced Diabetic Rats

The present research was carried out to investigate the potential hypoglycemic and hypolipidemic effect of leaf extract of Nepenthes khasiana Hook in Dexamethazone-induced Hyperlipidemia and Insulin Resistance in Rats. The experiment was done at two different doses of 250 & 500 mg/kg p.o. on day 11 of treatment, blood was collected for the estimation of serum glucose and lipid parameters. The effect of leaf extract was compared with standard glibenclamide at a dose of 500 mg/kg p.o. Leaf extract and glibenclamide significantly decreased ( P<0.05) dexamethazone induced elevation of serum glucose when compared to the control group. Leaf extract at a dose of 500 mg/kg showed better activity than standard. In conclusion, the present study indicated that leaf extract of Nepenthes khasiana Hook show significant glucose and lipid lowering activity.