Clinical study on lung diffusing capacity and influencing factors of 105 leukemia patients

Objective To observe the changes of lung diffusing capacity of leukemia patients, and explore the influencing factors of diffusing capacity. Methods Clinical data of 105 patients with leukemia from January 2012 to May 2017 were reviewed.Diffusing capacity without Hb adjustment and diffusing capacity with Hb adjustment were recorded, and the date were analyzed by SPSS19 software. Results The values of DLCO、DLCO/VA reveal significant changes between Hb uncorrected and corrected in three groups (Hb normal, mild and moderate-severe reduction group)(P 0.05), but there were significant differences in the Hb mild reduction group (P<0.01) and Hb moderate-severe reduction group (P<0.01). Transplantation and anemia were high risk factors that affect the categories of diffusing capacity without adjustment. Conclusions There exist differences in the values of DLCO without/with Hb adjustment of leukemia patients.The categories of diffusing capacity are changed significantly between Hb uncorrected and corrected group when patients with anemia.While clinically analyzing diffusing capacity, the Hb factor should be excluded firstly. Key words: Leukemia; Diffusing capacity; Anemia; Hemoglobin; Adjustment