Morphological Characterization of Experimental Amebic Liver Lesions in Gerbils

Gerbils are susceptlbie to amebic liver abscess (ALA) production under experimental conditions. However, little Is known about the histopathological changes that occur during the evolution of the lesion. We analyzed microscopically the sequence of cellular events of ALA In gerbils inoculated intraportally or intrahepatically with E. histoijJtica. At early stages trophozoites wereassodated with different degrees of inflammatory reaction. Amebas were also observed in areas devoid of inflammatory cells. Damaged hepatocytes were either related or not to Inflam