ON THE MECHANISM OF THE INHIBITION OF MERCURIAL DIURESIS BY p-CHLOROMERCURIBENZOIC ACID
1962
The mechanism by which the nondiuretic mercurial, p -chloromercuribenzoic acid ( p -CMB), prevents and reverses mercurial diuresis has been studied in different types of experiments. Histochemical data are presented which indicate that the reduction in protein-bound sulfhydryl concentrations in cells of the renal tubules in rats produced by p -CMB is not additive with that produced by diuretic mercurials, while the effects of two diuretic mercurials are additive. Measurement in dogs of the mercury 203 content of plugs of renal cortex, before and after injection of p -CMB, indicates that p -CMB displaces diuretic mercury from the kidney in proportion to the dose administered. This renal loss of mercury is due to an increased loss of mercury in the urine and to the blood which leaves the kidney. The dose-response relationship between diuretic mercuric glutathione and p -CMB has been studied in acidotic and alkalotic dogs and indicates that the 50% blocking dose is not related to the diuretic dose in a simple or direct way. The reasons for this are discussed. The experiments provide evidence that only a small amount of mercury is involved in the production of the diuresis, and that mercaptide formation is not per se the cause of diuresis, but is an essential part of the interaction between mercury and its renal receptor.
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