Thermal stability and decompositions kinetics under non-isothermal conditions of imatinib mesylate α form.

Abstract The thermal decomposition and kinetic parameters of synthetized imatinib mesylate α form α form were determined by thermogravimetry (TGA/DTG) under non-isothermal conditions. The experiments were performed at a 25–940 °C temperature range at five different heating rates: 2.5 K min −1 , 5 K min −1 , 10 K min −1 , 15 K min −1 and 20 K min −1 per minute in a nitrogen atmosphere. Imatinib mesylate α form presents one-step mass loss during the degradation process. The thermal stability of the examined material, the melting temperature ( T onse t  = 220.6 °C) and ΔH fusion = −95.74 J g −1 at a heating rate of 10 °C min −1 was established. The values of activation energies have been estimated using Kissinger, Flynn–Wall–Ozawa (FWO) and Kissinger–Akahira–Sunose (KAS) methods.