Effect of histamine on technetium-99m excretion by gastric mucosa

The ability of histamine to increase excretion of /sup 99m/Te by gastric mucosa was investigated in dogs with Heidenhain pouches and denervated antral pouches. Histamine increased Heidenhain pouch /sup 99m/Te output in a dose-related manner, and /sup 99m/Te output was related linearly to acid output. Antral pouch /sup 99m/Te output was unchanged by increasing doses of histamine. The study suggests that concomitant use of histamine may improve the accuracy of /sup 99m/Te scanning in the clinical diagnosis of conditions caused by ectopic gastric mucosa.