Breast cancer detection using Ktrans MRI imaging to guide near infrared spectroscopy tomography

The parametric image of Volume Transfer Coefficient (K trans ) in MRI has been used to guide image reconstruction of Near-Infrared Spectral Tomography (NIRST). The image reconstruction used direct regularization, in which no segmentation has been involved. A total of 24 patients were involved in this study and the reconstructed results show that the tumor total hemoglobin (HbT) contrast could be used to differentiate the malignant from the benign cases (p-value= 0.018). The addition of the MRI information allows more accurate and definitive HbT values from the NIRST.