In older patients with permanent AF and HF, digoxin and bisoprolol did not differ for QoL at 6 mo.

2021 
SOURCE CITATION Kotecha D, Bunting KV, Gill SK, et al. Effect of digoxin vs bisoprolol for heart rate control in atrial fibrillation on patient-reported quality of life: the RATE-AF randomized clinical trial. JAMA. 2020;324:2497-508. 33351042.
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