Comparatve Study of Frozen Secton Diagnoses with Histopathology

The correlaton of intraoperatve frozen secton diagnosis with fnal diagnosis on permanent secton is an integral part of quality assurance in surgical pathology. The present study was a retrospectve analysis of 404 cases of frozen secton biopsy, reported in the BPKMCH pathological department between January 2003 to December 2007. The frozen secton diagnoses were correlated with the fnal histological diagnosis to assess the accuracy of the technique. The number and type of discrepancies were compared the indicaton, causes for the discrepancies and deferrals were analyzed in order to decrease the avoidable errors and improve on the frozen secton diagnosis. The overall accuracy over 5 years was 94.6% with false positve rate of 1.5%, false negatve rate of 3.9% and 3.9% of deferred diagnosis. The achieved results in the present study were comparable with the published results. The discrepancies were mainly due to the interpretaton error, sampling error, technical artfacts and partly due to lack of interdepartmental communicaton. Frozen secton diagnosis is very useful and highly accurate procedure. Gross inspecton, sampling by pathologist, frozen complemented with cytological and histological review and intmal cooperaton with surgeon can avoid certain limitatons and provide rapid, reliable, cost efectve informaton necessary for optmum patent care.