MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU

Elena Favaro,Anassuya Ramachandran,Robert McCormick,Harriet E. Gee,Christine Blancher,Meredith E. Crosby,Cecilia Devlin,Christopher Blick,Francesca M. Buffa,Ji-Liang Li,Borivoj Vojnovic,Ricardo Pires das Neves,Peter M. Glazer,Francisco J. Iborra,Mircea Ivan,Jiannis Ragoussis,Adrian L. Harris

MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU

2010

Elena Favaro
Anassuya Ramachandran
Robert McCormick
Harriet E. Gee
Christine Blancher
Meredith E. Crosby
Cecilia Devlin
Christopher Blick
Francesca M. Buffa
Ji-Liang Li
Borivoj Vojnovic
Ricardo Pires das Neves
Peter M. Glazer
Francisco J. Iborra
Mircea Ivan
Jiannis Ragoussis
Adrian L. Harris

Background Hypoxia in cancers results in the upregulation of hypoxia inducible factor 1 (HIF-1) and a microRNA, hsa-miR-210 (miR-210) which is associated with a poor prognosis.

Keywords:

Cancer cell
Cell biology
microRNA
Hypoxia (medical)
Transfection
ISCU
Downregulation and upregulation
Citric acid cycle
Biochemistry
Biology
Mitochondrion

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