Increased cell surface expression of histocompatibility class II IAd in c-FOS transfected clones of the P388D1 murine macrophage cell line.

INTRODUCTION Class II MHC antigens are cell surface, heterodimeric proteins which present antigens to CD4+ T lymphocytes and thus play a crucial role in the regulation of the immune response [1]. The expression of class II antigens is restricted to a few types of immune cells (dendritic cells, macrophages, activated T cells, B lymphocytes and thymic epithelium). The ability to present antigens is dependent on the number of class II [...]