Design, Synthesis and Bioevaluation of New Urea/Thiourea Derivatives of 3,5-dichloro-4-hydroxy-aniline

Synthesis of a series of new urea and thiourea derivatives of 3,5-dichloro-4-hydroxyaniline was accomplished by reacting various isocyanates and isothiocyanates in the presence of triethylamine at 60°C. All the title compounds obtained in high yields and they were characterized by IR, 1H, 13C-NMR, mass spectral and elemental analysis. All the title compounds exhibited potent antioxidant and antimicrobial activities.