In situ formation of porous mineral–polymer scaffold for tissue engineering

A principle of three-dimensional printing of composite materials with structure and properties close to natural human tissues was implemented. It was found that the inorganic component, dicalcium phosphate dihydrate, crystallizes in the bulk of alginate matrix. The subsequent chemical treatment of experimental samples in buffered solutions promoted the formation of octacalcium phosphate on the surface of pore space of the printed material.