Long-term Results after Total Thyroidectomy in Patients with Graves' Disease in Uzbekistan: Retrospective Study

Subtotal thyroidectomy has been advocated as the standard treatment for Graves' disease (GD) because of the assumed lower risk ofcomplications compared with total thyroidectomy, and also it provides the chance to avoid thyroxin therapy. The present study aims toexamine our institutional experience with total thyroidectomy for GD. Patients were divided into two surgical treatment groups: Totalthyroidectomy (TT) (n = 97) and total thyroidectomy with intraoperative thyroid autotransplantation (TTITA) (n = 74). TTITA performed in 74patients. 0.5 to 2 gm of thyroid tissue was cut into small pieces and autotransplanted into the forearm muscle of the patient. Postoperativecomplications included eight cases of RLN palsy, two patients had nerve paralysis, two patients underwent tracheostomy, transienthypoparathyroidism in 25 patients, permanent hypoparathyroidism in two cases, wound hemorrhage in two patients. TPOAb levels wereincreased in 9% of patients with TT whereas in patients with TTITA TPOAb concentrations were elevated in 65% of patients at 3 monthsfollow-up. TRAb in patients with TT were not detected while 20% patients undergone TTITA had high TRAb levels and 13.3% had terminalconcentrations at 3 months follow-up. Serum TPOAb and TRAb were detected in none of the patients who underwent TT and TTITA at 1,3 and 5 years follow-up. Removal of all thyroid tissue offers the best chance of preventing recurrent hyperthyroidism and we saw noincrease in postoperative complications in the TT group. We feel that TT is safe and superior for achieving the goal of treatment of Graves'disease.