Recent advances in the machine learning-based drug-target interaction prediction
2018
BACKGROUND: The identification of drug-target interactions is a crucial issue in drug discovery. In recent years, researchers have made great efforts on the drug-target interaction predictions, and developed databases, software and computational methods. RESULTS: In the paper, we review the recent advances in machine learning-based drug-target interaction prediction. First, we briefly introduce the datasets and data, and summarize features for drugs and targets which can be extracted from different data. Since drug-drug similarity and target-target similarity are important for many machine learning prediction models, we introduce how to calculate similarities based on data or features. Different machine learningbased drug-target interaction prediction methods can be proposed by using different features or information. Thus, we summarize, analyze and compare different machine learning-based prediction methods. CONCLUSION: This study provides the guide to the development of computational methods for the drug-target interaction prediction.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
94
References
23
Citations
NaN
KQI