Spindle cell cancer of bladder during cyclophosphamide therapy for Wegener's granulomatosis

ABSTRACTA 38-year-old woman with long-standing Wegener's granulomatosis had remission with cyclophosphamide therapy after failure of response to other agents. Severe cystitis with massive blood loss necessitated a cystectomy. The bladder contained an unsuspected neoplasm, histologically resembling l