Sub-acute Toxicological Effects of Jobelyn® on Pregnant AlbinoRats
2018
The aim of the present study was to investigate the sub-acute toxicological effects of Jobelyn® on pregnant
albino rats by employing biochemical, haematological and histopathological methods. A total of 32 pregnant female rats
were randomly assigned to four different groups of eight rats each. The control group received distilled water and
different doses of Jobelyn®; 250, 500, 1000 mg kg-1were administered orally once a day for 2 weeks to the other groups.
Biochemical analysis revealed a significant decrease (p<0.05) in the levels of alanine aminotransferase, albumin, urea,
PCV and Hb in the treatment groups when compared to the control. However, the significant decrease in PCV and Hb
was observed solely in the group treated with 1000 mg kg-1body weight, suggesting that this decrease could be dosedependent.
Alkaline phosphatase, total protein, triglycerides, cholesterol, HDL cholesterol, LDL cholesterol, eosinophils,
basophils, neutrophils, monocytes, lymphocytes, WBC count, revealed no significant difference (p<0.05) when compared
to the control. The results show that at an appropriate dosage, the use of Jobelyn® during pregnancy may have no adverse
effect on the liver and kidney tissues and may possess hepatoprotective and nephroprotective properties however the
histopathological studies revealed that very high levels of Jobelyn may be hepatotoxic
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