1134. Intratumoral Injection of Dendritic Cells Engineered to Secrete Interleukin-12 by Recombinant Adenovirus in Patients with Metastatic Gastrointestinal Carcinomas

Guillermo Mazzolini,Carlos Alfaro,Bruno Sangro,Esperanza Feijoo,Juan Ruiz,Alberto Benito,Iñigo Tirapu,Ainhoa Arina,J. Sola,Maite Herraiz,Felipe Lucena,Cristina Olagüe,Jose Carlos Subtil,Jorge Quiroga,Ignacio Herrero,Belén Sádaba,Maurizio Bendandi,Cheng Qian,Jesús Prieto,Ignacio Melero

1134. Intratumoral Injection of Dendritic Cells Engineered to Secrete Interleukin-12 by Recombinant Adenovirus in Patients with Metastatic Gastrointestinal Carcinomas

2005

Purpose: To evaluate the feasibility and safety of intratumoral injection of autologous dendritic cells (DC) transfected with an adenovirus encoding interleukin- 12 genes (AFIL-12) for patients with metastatic gastrointestinal carcinomas. Secondarily, we have evaluated biological effects and antitumoral activity.

Keywords:

Virology
Autologous dendritic cells
Dendritic cell
Secretion
Transfection
Side effect
Interleukin
Biology
Recombinant DNA
Interleukin 12
Molecular biology
in patient
Gene

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