Clicking into Place: Interfacing Terminal Alkyne Biosynthesis with Polyketide Synthases.
2020
Engineering polyketide biosynthesis to enable the production of diverse chemical structures is a major challenge at present. Utilising an established biosynthetic cassette for terminal alkyne production, Porterfield et al. applied docking domain and site-directed mutagenesis approaches to interface these enzymes with modular polyketide synthase (PKS) enzymes, yielding products with a bio-orthogonal handle.
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