Estrogen-Dependent Nrf2 Expression Protects Against Reflux-Induced Esophagitis
2018
Background
Gastroesophageal reflux disease is more common in males than in females. The enhanced antioxidative capacity of estrogen in females might account for the gender difference. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a pivotal role in the host defense mechanism against oxidative stress.
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