Clinical and histological characterization of vesicular COVID-19 rashes: A prospective study in a tertiary care hospital.

: Vesicular skin rashes have been associated to the Coronavirus Disease 2019 (COVID-19), but there is little information about this cutaneous manifestation. We designed a prospective observational study of patients diagnosed with COVID-19 and vesicular lesions. Clinical characterization of skin findings was conducted by dermatologists. When possible, histological analysis and detection of severe acute respiratory coronavirus 2 (SARS-CoV-2) in the content of the vesicles was performed. A total of 24 patients were included. A disseminated pattern was found in 18 patients (75%), and a localized pattern was found in 6 patients (25%). The median duration of the skin rash was of 10 days. Out of all, 19 patients (79.2%) presented the skin rash after the onset of COVID-19 symptoms. Histologic examination in two patients was consistent with viral infection, SARS-CoV-2 was not detected in four patients. This monocentric study shows the clinical characteristics of vesicular skin rashes in COVID-19 patients.