Adjuvanted Influenza Vaccines Elicits Higher Antibody Responses against the A(H3N2) Subtype than Non-Adjuvanted Vaccines.

Background: VacCI nation is the best approach to prevent influenza infections so far. Serological studies on the effect of different vacCI ne types are important to address vacCI nation campaigns and protect our population. In our study, we compared the serological response against influenza A subtypes using the non-adjuvanted influenza vacCI ne (NAIV) in adults and the elderly and the adjuvanted influenza vacCI ne (AIV) in the elderly. Methods: We performed a retrospective analysis by hemagglutination inhibition assay (HI) of serum samples right before and 28 days after seasonal influenza vacCI nation during the 1996–2017 seasons. Conclusions: The AIV presents better performance against the A(H3N2) subtype in the elderly whereas the NAIV induces a better response against A(H1N1)pdm09 in the same group.