Effect of Extract Black Cumin (Nigela Sativa) on the LDL/HDL Ratio of Ovariectomized White Mouse (Rattus Novergicus Strain Wistas)

Changes in fat metabolism by estrogen deficiency is one of the factors increasing the risk of CHD in postmenopausal women. Black cumin (Nigella sativa) is a spice that can be used as a medicinal plant. From several studies, Nigella sativa could show the effects of estrogen. Objective: to determine the effect of black cumin (Nigella sativa) against changes on LDL/HDL ratio of the ovariectomized white mouse (Rattus novergicus wistar strain) Method : True Experimental design with the post test only control group design with 25 female mouse divided into five groups : 2 controle group positive and negative, and 3 treatment groups of black cumin extract at a dose of 1.25, 2.5 and 5 mg/kg BW /day. Results : One way ANOVA test showed the non significant value (p > 0.05) of weight changes (p: 0.055), HDL level (p : 0.326) and LDL level ( p: 0.659). At Kruskal-Wallis test showed the non significant value of LDL/HDL ratio (p : 0.152 (p > 0.05)). Conclusion : Extract of black cumin (N. sativa) could not significant affect on LDL/HDL ratio of the ovariectomized white mouse (Rattus novergicus wistar strain)