Trimethoprim, Metioprim, Tetroxoprim, and RO 10-5970 in Canine Bone

: The penetration of trimethoprim and three derivatives into bone tissue was investigated in a dog model. Our data demonstrated that the trimethoprim derivative RO 10–5970 concentrates well in bone tissue with median tissue-to-serum concentration ratios of 0.23 in cortical bone and 0.81 in both medulla and cancellous bone. The use of RO 10–5970 in osseous infections is appealing because oral administration is possible; therefore, clinical trials appear warranted.