A Longitudinal Study of Human Papillomavirus Carriage in Human Immunodeficiency Virus-Infected and Human Immunodeficiency Virus-Uninfected Women

Abstract OBJECTIVE: We sought to determine the relationship of human immunodeficiency virus serostatus to carriage of oncogenic human papillomavirus. MATERIAL AND METHODS: A total of 268 human immunodeficiency virus–infected and 265 human immunodeficiency virus–uninfected women were seen every 6 months, at which time they had laboratory tests performed including a CD4 count. Human papillomavirus deoxyribonucleic acid was analyzed by polymerase chain reaction. Statistical methods included Kaplan-Meier and Cox's proportional hazard models. RESULTS: The prevalence at baseline of any human papillomavirus type was 73% and 43% among human immunodeficiency virus–seropositive and seronegative women, respectively ( p p 3 ( p p p CONCLUSIONS: Human immunodeficiency virus–seropositive women are more likely to have newly detectable oncogenic types of human papillomavirus at follow-up and to show persistent carriage of oncogenic types of human papillomavirus types. Among human immunodeficiency virus–infected women, those with higher CD4 counts were more likely to have a newly detected oncogenic human papillomavirus during follow-up. (Am J Obstet Gynecol 1998;178:982-6.)