Granulomatous uveitis, CREST syndrome, and primary biliary cirrhosis

Editor,—There is a well known link between different autoimmune diseases. Up to 84% of patients with primary biliary cirrhosis (PBC) may have at least one other autoimmune disease, such as thyroiditis, scleroderma, rheumatoid arthritis, or Sjogren's syndrome.1 The association between uveitis and scleroderma although rare is well recognised,2 but we failed to find a single report of the association of uveitis and CREST syndrome (calcinosis cutis, Raynaud's phenomenon, oesophageal dismotility, sclerodactyly, and telangiectasia), a more benign variant of scleroderma in the form of limited cutaneous sclerosis. The simultaneous occurrence of PBC and uveitis is probably also very unusual as we could only find one such case report in our literature search.3 We report the case of a patient with uveitis whose investigation disclosed PBC and CREST. ### CASE REPORT A 48 year old woman with a longstanding history of Raynaud's phenomenon complained …