An Iodinatable Photoaffinity Probe Based on the Structure of Kallidin

Binding sites for the peptides bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg; Bk) and kallidin (N-lysyl-bradykinin) have been described on many tissues. These include various smooth muscle preparations such as uterus and ileum, blood vessels, and the processes of nociceptive afferent neurons (Erdos, 1979). In addition, binding sites have been described on cultured fibroblasts and on cell lines such as the neuroblastoma-glioma hybrid NG108-15, (Hamprecht, 1977) where they probably correspond to physiologically active Bk receptors.