An Improved SPE―LC―MS―MS Platform for the Simultaneous Quantification of Multiple Amyloid β Peptides in Cerebrospinal Fluid for Preclinical or Biomarker Discovery

2011 
INT RODUCT ION A previous application note (720003682en) described in detail the development of a fast, flexible SPE/LC/MS/MS platform for the quantification of multiple amyloid beta (aβ) peptides from human or monkey CSF for use in a biomarker or preclinical discovery setting. In this work, the mass spectrometry platform has been updated from the Xevo® TQ MS to the Xevo TQ-S mass spectrometry system. This change facilitated both a 4X reduction in required sample size and a 4-5X increase in assay sensitivity.
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