322. Patients with Refractory Systemic Lupus Erythematosus Requiring Biologic Therapy Have Significant Levels of Baseline Co-Morbidities: Results from a National Multi-Centre Register

Emily J. Sutton, Kath D. Watson, David Isenberg, Anisur Rahman, David Jayne, Caroline Gordon, Chee-Seng Yee, Peter Lanyon, Edward M. Vital, David D’Cruz, Munther Khamashta, Pamela Lutalo, Mohammed Akil, Chris Edwards, Nicola Erb, Athiveer Prabu, Hazem Youssef, Asad Zoma, Neil McHugh, Nicole Amft, Bridget Griffiths, LeeSuan Teh and Ian Bruce Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, Centre for Rheumatology, University College London, London, Department of Nephrology, Addenbrooke’s Hospital, Cambridge, Rheumatology Research Group, The University of Birmingham, Birmingham, Department of Rheumatology, Doncaster Royal Infirmary, Doncaster, Department of Rheumatology, Nottingham University Hospital NHS Trust, Nottingham, Department of Rheumatology, Leeds Teaching Hospitals NHS Trust, Leeds, Louise Coote Lupus Unit, St Thomas’ Hospital, London, The Rayne Institute, St Thomas’ Hospital, London, Department of Rheumatology, Sheffield Hallamshire Hospital, Sheffield, Department of Rheumatology, Southampton General Hospital, Southampton, Department of Rheumatology, The Dudley Group NHS Foundation Trust, Dudley, Department of Rheumatology, Worcestershire Acute Hospitals NHS Trust, Worcester, Department of Rheumatology, Aberdeen Royal Infirmary, Aberdeen, Department of Rheumatology, Hairmyres Hospital, Lanarkshire, Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, Rheumatic Diseases Unit, Western General Hospital, Edinburgh, Department of Rheumatology, Freeman Hospital, Newcastle-upon-Tyne, Department of Rheumatology, Royal Blackburn Hospital, Blackburn, UK