Influence of aerobic exercise on oxidative stress and PPARα in myocardium in metabolic syndrome rats

OBJECTIVE: This experiment was to investigate the effect of aerobic exercise on oxidative stress response and expression of peroxisome proliferator activated receport α( PPARα) in cardiovascular of metabolic syndrome( MS) rat. METHODS: 49 4-week male rats were randomly assigned to two groups: control group( C) with 6 rats with normal diet and MS model group with 43 rats with high fat diet. After 18 weeks, assigned the successful MS modeling high fat diet rats to model control group( MC) with 8 rats and model exercise group( ME) with 8 rats. The ME rats exerted aerobic treadmill exercise 12 weeks. Concurrent execution all rats to test the oxidative stress factors in serum including monocyte chemoattractant protein 1( MCP-1), plasminogen activator inhibitor 1( PAI-1), oxidized low density lipoprotein( ox-LDL), endothelial nitric oxide synthase( e NOS) andPPARα mRNA expression and protein content in myocardium. RESULTS: Compared to C group, MC group rats PAI-1, ox-LDL, e NOS showed increased in serum( P < 0. 05 or P < 0. 01) and PPARα mRNA expression and the protein content decreased significantly( P < 0. 01, P < 0. 05) in myocardium. Compare to MC group, ME group rats MCP-1, PAI-1 showed decreased with statistically significant( P < 0. 05, P < 0. 01) and ox-LDL decreased but without statistical difference in serum and e NOS increased without statistically significant, PPARα mRNA expression increased( P < 0. 05) with the protein content increased with statistically significants( P < 0. 01) in myocardium. CONCLUSION: Oxidative stress increased in MS rats, aerobic exercise could decrease the oxidative stress to reducing the damage of oxidative stress in cardiovascular. The possible mechanism of exercise anti-oxidation stress was the changed PPARα transcription and translation by exercise mediated oxidation stress response in cardiovascular.