Interaction between asymmetric solutes and solvents. Diamides derived from L-valine as stationary phases in gas-liquid partition chromatography.

Abstract The resolution of enantiomers of (±)-α-amino acid derivatives on optically active diamides derived from l -valine, R 1 CONHCH[CH(CH 3 ) 2 ]CONHR 2 , as gas chromatographic stationary phases was studied. The effects of the structure of R 1 and R 2 in the stationary phases, the structure of the racemic α-amino acid derivatives, temperature, etc., on the separation factors are reported. In the light of these and related results, a more probable mechanism of resolution is presented.