Efficacy evaluation of laparoscopic gastric bypass for the treatment of obese type 2 diabetes mellitus

Objective To explore the treatment outcomes of obese type 2 diabetes mellitus(T2DM)after laparoscopic gastric bypass.Methods The clinical data of 18 patients with obese T2DM who underwent laparoscopic Roux-en-Y gastric bypass in Beijing Shijitan Hospital between March 2009 and February 2011 were retrospectively analyzed.The clinical parameters included preoperative and postoperative blood glucose,blood lipid,nutrition status and weight lose.Results Eighteen patients included 8 men and 10 women.The range of age was 27-62 years(mean,42.4±10.7 years).The range of BMI was 28.7-57.4 kg/m2(mean,34.9±6.9 kg/m2).All the patients underwent laparoscopic Rouxen-Y gastric bypass,and no mortality,complication or conversion to open operation occurred.At 3 months after operation,there were significant changes in OGTT,BMI,HbA1c,Homa-IR and Homa-β(all P＜0.05).Fourteen patients(77.8％)showed clinical complete remission,and the overall effective rate was 100％(18/18).The level of blood lipid decreased significantly(P＜0.05),and the change of nutritional status was not statistically significant(P＞0.05).Conclusion Gastric bypass is an effective treatment for obese type 2 diabetes mellitus. Key words: Type 2 diabetes mellitus; Obesity; Gastric bypass; Laparoscopy; Treatment outcomes