Diuretic effect of torasemil for children with nephrotic syndrome

Objective To observe the influences of torasemil versus furasemide on diuretic effect in children with nephrotic syndrome. Methods Sixty-eight children with nephrotic syndrome treated with oral prednisone were randomly divided into a torasemib group and a furosamib group, with 34 cases in each group. The torasemib group were intravenously dripped torasemib, 1 mg/(kg•d), once a day; the furasemide group were intravenous dripped furasemide, 1 mg/(kg•d), once a day. The clinical treatment efficacy and the changes of blood electrolytes, renal functionand, and 24 h urine volume before and after the treatment of the two groups were compared. Results Day 2, 5, and 7 after the treatment, the urine volumes were (958.78±96.83) ml/d, (1 283.88±117.35) ml/d, and (1 368.72±132.35) ml/d in the torasemibe group, which were higher than those in the furosemide group (all P 0.05). The serum creatinine and blood urea nitrogen levels were better in the torasemibe group than in the furosemide group after the treatment. Conclusion The potassium and diuretic effects of torasemibe are stronger than those of furosemide, and can improve the children’ renal function to a certain extent. Torasemibe in the treatment of children with nephrotic syndrome edema has better therapeutic effect and safety than furosemide. Key words: Children; Nephrotic syndrome; Torasemide; Furosemide; Edema