Sugar modified anti-glypican 3 antibody

Anti-glypican 3 antibody and sugar chain-modified anti-glypican 3 antibody fucose deficient are disclosed more specifically. Anti-glypican 3 antibody of the present invention, the code in the method for producing an antibody in which the sugar chain has been modified, the anti-glypican 3 antibody into host cells or fucose transporter-deficient cells fucose addition capability such as YB2 / 0 cells was reduced a nucleic acid introduced can be produced by culturing the host cells. Glycan modifying anti-glypican 3 antibody of the present invention has a high cytotoxic activity and are useful as cytostatic agents such as anti-cancer agents.