Proteomics Detection of Endothelial Cell Surface Proteins Following Irradiation as Potential Targets for Brain Arteriovenous Malformations Molecular Therapy

Arteriovenous malformations (AVMs) in the brain are vascular neurological lesions consist of abnormal collection of arteries and veins. They are the most common cause of brain haemorrhage in children and young adults. Over 90% of large AVMs (>3 cm) are not curable, or curable with unacceptable risks. Radiosurgery is the treatment option for lesions (< 3cm) in diameter and located in eloquent areas where surgery can cause neurological defecit. However vascular occlusion post radiosurgery can takes up to 3 year to complete while patients remain at risk of haemorrhage. This study aims to develop a molecular therapy for human brain AVMs. Specifically we aim to identify unique protein targets of AVMs that are up-regulated post irradiation. These proteins will then be used to develop a ligand-directed vascular treatment that promotes rapid thrombosis in AVM vessels post radiosurgery.