Insulin resistance accelerated the clearance of resveratrol: A note of caution

Abstract Trans-resveratrol (RES), a well-known polyphenol exerts various health-promoting benefits, including glucose homeostasis maintenance. Here, we have investigated the impact of insulin resistance (IR) on RES disposition. Rats were fed with 10%-fructose-water for 8 weeks for developing IR. The systemic exposure to RES significantly decreased (IR vs normal, AUC 0-24h , 1.73, 3.79, 9.27 vs 2.50, 6.12, 12.6 μM∙h, 20, 50, 100 mg/kg, p