Assessment oftheonehouradrenocorticotro phic hormone test inthediagnosis ofattentuated 21-hydroxylase deficiency

or partial 21-hydroxylase deficiency isoneofseveral biochemical defects insteroid metabolism thatcan leadto hirsutismin young women afterpuberty. The diagnosis ismade through theexaggerated response of17a- hydroxyprogesterone (17-OH) to adrenocorticotrophic hormone(ACTH). To providereference data72mildto moderately hirsute patients aged18to35 werestudied (overtwoyears) withthe ACTH test.Four patients with an exaggerated responsewere found.The