Biotransformation of 4 ent-labdane diterpenoid lactones of Andrographis paniculata:recent progress

Ent-labdane diterpenoid lactones,the principal constituents of Andrographis paniculata,have a wide range of pharmacological effects,such as antibacterial,anti-viral,anti-inflammatory,antipyretic,and anti-cancer effect,etc.In this review the biotransformations of four principal ent-labdane diterpenoid lactones of A.paniculata are discussed from the following aspects:substrates and types of reaction,transformation systems,and structure activity relationships.Moreover,the currently-existing problems and the prospects are also described to provide reference for further studying the biotransformation of ent-labdane diterpenoid lactones of A.paniculata.