Systems Approach to Integrating Preclinical Apolipoprotein E-Knockout Investigations Reveals Novel Etiologic Pathways and Master Atherosclerosis Network in Humans.

Megan M. Shuey,Rachel R. Xiang,M. Elizabeth Moss,Brigett Carvajal,Yihua Wang,Nicholas Camarda,Daniel Fabbri,Protiva Rahman,Jacob Ramsey,Alec Stepanian,Paola Sebastiani,Quinn S. Wells,Joshua A. Beckman,Iris Z. Jaffe

Systems Approach to Integrating Preclinical Apolipoprotein E-Knockout Investigations Reveals Novel Etiologic Pathways and Master Atherosclerosis Network in Humans.

2021

Megan M. Shuey
Rachel R. Xiang
M. Elizabeth Moss
Brigett Carvajal
Yihua Wang
Nicholas Camarda
Daniel Fabbri
Protiva Rahman
Jacob Ramsey
Alec Stepanian
Paola Sebastiani
Quinn S. Wells
Joshua A. Beckman
Iris Z. Jaffe

Objective: Animal models of atherosclerosis are used extensively to interrogate molecular mechanisms in serial fashion. We tested whether a novel systems biology approach to integration of preclini...

Keywords:

Computational biology
Apolipoprotein E
Systems biology
Biology
Retinoid
myeloid cells
Gene expression

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