DERIVATIVES -pyrazolo (3,4- d) -pyrimidine LIKE AGENT antiproliferative.

A compound which is one according to Formula (I), wherein R is lower alkyl; ring A is selected from the group consisting of: heteroaryl; heteroaryl substituted by 1 to 5 substituents independently selected from the group consisting of lower alkyl; halogen; I hydroxyl; lower alkoxy; lower alkoxy substituted by hydroxyl or lower alkoxy; and cyano; phenyl; and phenyl substituted by 1 to 4 substituents independently selected from the group consisting of lower alkyl; halogen; I hydroxyl; lower alkoxy; lower alkoxy substituted by hydroxyl or lower alkoxy; and cyano; ring B is selected from the group consisting of: heteroaryl; heteroaryl substituted by 1 to 5 substituents selected from the group consisting of lower alkyl; fluorinated alkyl; alkyl substituted with aryl; I hydroxyl; lower alkoxy; lower alkoxy substituted by hydroxyl or lower alkoxy; halogen; and -NR 1 R 2; phenyl; and phenyl substituted by 1 to 5 substituents selected from the group consisting of lower alkyl; fluorinated alkyl; alkyl substituted with aryl; I hydroxyl; lower alkoxy; lower alkoxy substituted by hydroxyl or lower alkoxy; halogen; cyano; and -NR 1 R 2; R 1 and R 2 are independently selected from each other from the group consisting of hydrogen; lower alkyl; and substituted with hydroxyl or lower alkoxy lower alkyl; and R 1 and R 2 together with N, can form a heterocyclic ring of 5 or 6 membered; and L is selected from the group consisting of a bond, -OCH2-, -CH2O-, - NHCO-, -CONH-, -O-, -OCH2CH2-, -CH2OCH2, -CH2CH2O-, -CF = CH- , -CH = CF-, -NH-, -NHCH2-, -CH2NH-, -SCH2-, - 2 S-, -SOCH2-, -CH2SO-, -SO2CH2-, -CH2SO2-, -S-, -CH = CH-, and lower alkyl; and wherein the term "lower" refers to a group having 1 to 6 carbon atoms; with the proviso that when L is a bond, Ring B is an azole substituted by 1 to 4 substituents selected from the group consisting of: lower alkyl; fluorinated alkyl; alkyl substituted with aryl; I hydroxyl; lower alkoxy; lower alkoxy substituted by hydroxyl or lower alkoxy; halogen; cyano; and -NR 1 R 2; or a salt or pharmaceutically-acceptable ester of a compound according to Formula (I) ,.