Concept and State-of-the-Art

Purification of peptide arrays with a density of up to 10,000 different array members per cm² requires a concept compatible with the given array format: Synthesis artefacts must be removed in situ, i.e. without the loss of spatial information provided by the synthesis. In addition, the peptides have to be purified simultaneously because external purification of each array member would diminish the benefits gained from combinatorial synthesis and is not feasible for highly resolved arrays.