Capsaicinoids Supplementation Reduces Appetite and Body Circumferences in Healthy Men and Women A Placebo Controlled Randomized Double Blind Study

BackgroundConsumption of capsaicinoids (CAP), the bioactive and pungent principles in red hot pepper, has been shown to increase energy expenditure and may impact overall metabolism. In vivo studies suggest that supplementation of CAP could positively affect risk factors of cardiovascular health. Therefore, the purpose of this study was to examine the effects of different doses of CAP on appetite and body circumference in healthy men and women. MethodsIn a double blind, randomized, placebo controlled design seventy-seven (29.6 ± 11.3 y, 171.2 ± 9.8 cm, 80.9 ± 18.9 kg, 27.4 ± 5.4 kg/m2) apparently healthy males and females were randomly assigned by fat mass to ingest either CAP (2mg CAP, CX1 or 4mg CAP, CX2 [CX, Capsimax®, OmniActive Health Technologies Ltd.]) or placebo (corn starch, PLA) for 12 weeks. Subjects were requested not to make any changes to their current physical activity, provided instructions to restrict spicy foods and maintain current caloric intake. Subjects were instructed to take the pi...