Population Based Study of Co-Morbidity of Neurological Autoimmune Diseases and Thyroid Disease in Buenos Aires, Argentina (P4.025)

OBJECTIVE: To study the coexistence of thyroid disease (TD) in patients with Relapsing-Remitting Multiple Sclerosis (RRMS), Neuromyelitis Optica (NMO), Myasthenia Gravis (MG) and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) from a General Hospital in Buenos Aires, Argentina. BACKGROUND: Autoimmune diseases are complex disorders caused by a combination of genetic susceptibility and environmental factors. The current literature indicates in this population a coexistence of TD in the range of 9-30%. To our knowledge, this is the first population-based study that investigates the association of TD with MS, NMO, MG and CIDP patients in Argentinean population. DESIGN/METHODS: We reviewed the medical records of patients suffering MS, NMO, MG and CIDP seen at the Neuroinmmunology Clinic of the Hospital Dr. Jose Maria Ramos Mejia in Argentina during the period from 2006 to 2011. The data that we analyzed was the association of the studied population with TD. RESULTS: 284 patients were included. Of these, 46 patients (16.2 %) had TD. 38 ( 83 %) were hypothyroid and 8 (17 %) hyperthyroid. 6/58 MS patients (10.5 %), 26/101 MG patients (25.5%), 8/87 CIDP patients (9.2 %) and 6/38 NMO (16 %) patients had TD. Out of 46 patients with neurological autoimmune disease and TD, 11 (24 %) had another autoimmune disease. CONCLUSIONS: In the present study, 16.2 % of all patients had TD. MG and NMO patients showed higher prevalence of TD than MS and CIDP. This study emphasizes the need to actively look for TD in the studied population. Study Supported by: Disclosure: Dr. Villa has nothing to disclose. Dr. Aguirre has nothing to disclose. Dr. Melamud has nothing to disclose. Dr. Di Egidio has nothing to disclose. Dr. Alonso has nothing to disclose. Dr. Rey has nothing to disclose.