321: Additional rectal misoprostol plus intravenous oxytocin versus intravenous oxytocin for the prevention of postpartum hemorrhage after cesarean section

INTRAVENOUS OXYTOCIN FOR THE PREVENTION OF POSTPARTUM HEMORRHAGE AFTER CESAREAN SECTION SOON CHEOL HONG, JI WON KIM, HYUN TAE PARK, HYUN-JOO SEOL, HAI JOONG KIM, SUN HAENG KIM, KYU WAN LEE, Korea University Medical Center, Seoul, South Korea, Korea University Medical Center, , Sudan, Korea University Medical Center, Department of Obstetrics and Gynecology, Seoul, South Korea, Korea University Medical Center, Obstetrics and Gynecology, Seoul, South Korea, Korea University Medical Center, Obstetrics and Gynecolgy, Seoul, South Korea OBJECTIVE: To evaluate the value of additional rectal misoprostol in preventing the risk of postpartum hemorrhage after cesarean delivery STUDY DESIGN: Subjects were randomized to receive two, 200microgram misoprostol tablets rectally (study medication) plus 20 units oxytocin in Ringer fs lactate intravenously or two lactose talets rectally plus 20 units oxytocin in Ringer fs lactate intravenously (control medication). Our outcome measures were change in hemoglobin and hematocrit value from baseline to postpartum day 1, additional uterotonin, transfusion rate and side effects. RESULTS: There were no significant differences between two groups with regard to a drop in hemoglobin and hematocrit. The primary outcome measures were similar in the two groups CONCLUSION: Additional rectal misoprostol to intravenous oxytocin is not more effective than intravenous oxytocin for the prevention of postpartum hemorrhage after cesarean section