PREPARATION AND EVALUATION OF SOLID DISPERSION OF ASIATIC ACID WITH PVPK30

Solid dispersions of Asiatic acid with a hydrophilic polymer, namely, polyvinyl pyrrolidone (PVP) was prepared by the solvent evaporation method. The effect of Asiatic acid: PVPk30 feed ratio by weight on the aqueous solubility was investigated, the aqueous solubility of Asiatic acid reached 2043μg/ml when the weight ratio of Asiatic acid to PVPk30 was 1:5. The aqueous solubility of Asiatic acid was increased by 20-fold in Asiatic acid/ PVPk30 solid dispersions. The Asiatic acid/ PVPk30 solid dispersions system was characterized by Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and Scanning Electron Microscopy (SEM). The FTIR spectra of Asiatic acid/ PVPk30 solid dispersions showed that the presence of strong interactions between Asiatic acid and PVPk30. The SEM and DSC spectrum of Asiatic acid/ PVPk30 solid dispersions indicated Asiatic acid existed in amorphous state, this could be explained the fact that the aqueous solubility of Asiatic acid was increased.