Abstract 14380: Effects of Highly Absorptive Curcumin on Systolic and Diastolic Function in Hypertensive Patients with Left Ventricular Hypertrophy

Purpose: Signals activated by increased hemodynamic overload to the heart finally reach nuclei of cardiomyocytes, change patterns of gene expression and cause their maladaptive hypertrophy. Acetylation of hypertrophy-responsive transcription factors by an intrinsic histone acetyltransferase (HAT), p300, is a critical event during this process. Cardiac p300 activity is increased in common types of heart failure in which pathological cardiomyocyte overgrowth occurs in response to hemodynamic overload. A natural compound, curcumin (Cur), possesses HAT inhibitory activity with specificity for p300. We have demonstrated that Cur treatment prevents the deterioration of systolic function in two different rat models of heart failure, hypertension and myocardial infarction. Recently, by using a novel drug-delivery system, we have developed highly absorptive curcumin (HS-Cur). We hypothesized that HS-Cur improves LV function in hypertensive patients. Methods and Results: Twenty hypertensive patients received daily ...